✨ KPV — Barrier & Inflammation Support Peptide

What Is KPV?

KPV (Lys-Pro-Val) is a short, three–amino-acid peptide derived from α-melanocyte-stimulating hormone (α-MSH). It is studied for its ability to support inflammation balance at barrier tissues — including the gut lining, skin, and ocular surface — without the pigmenting effects associated with full α-MSH.

Because of this non-pigmenting profile, KPV has become a focused tool in epithelial and inflammation research.

🌿 What KPV May Support

✔ Inflammation balance at barrier tissues
✔ NF-κB pathway regulation
✔ Gut, skin, and epithelial integrity research
✔ Tissue calm & recovery signaling
✔ Non-pigmenting melanocortin-derived activity

🔬 How KPV Works (Simplified)

Research suggests KPV helps regulate NF-κB, a central signaling pathway involved in inflammatory responses at epithelial surfaces. Unlike full α-MSH, KPV retains anti-inflammatory signaling without triggering pigmentation pathways, making it especially valuable in skin and ocular research contexts.

In intestinal models, KPV is taken up directly by epithelial cells via peptide transport systems, allowing for localized inflammation modulation rather than systemic effects.

⭐ Why Researchers Use KPV

KPV is commonly explored in studies involving:

• Gut and intestinal barrier models
• Skin and keratinocyte inflammation
• Ocular surface and corneal repair research
• Cytokine and epithelial stress signaling
• Non-pigmenting anti-inflammatory pathways

Its precision, simplicity, and tissue-focused action distinguish it from larger peptides with broader systemic activity.

🧬 Key Features

• α-MSH–derived tripeptide (Lys-Pro-Val)
• Non-pigmenting by design
• Focused NF-κB pathway modulation
• Studied primarily at epithelial barriers
• Small, stable peptide structure

⭐ For Research Use Only